Corresponding author: Swarup A V Shah, PhD; Senior Molecular Scientist -Human Genetics, Hinduja Hospital, Department of Laboratory Medicine [Biochemistry section] Mahim, Mumbai 400016. India;

India is undergoing a transformative shift toward precision healthcare, driven by the convergence of large-scale omics initiatives and digital health innovations. This article reviews three landmark programs, Genome India, Phenome India, and the Bharat Cancer Genome Atlas (BCGA), that are systematically mapping the nation’s genomic, phenotypic, and cancer-specific diversity. Together, these projects aim to enhance disease prediction, early diagnosis, and personalized treatment for the Indian population by building comprehensive and publicly accessible data resources. Simultaneously, India’s digital health ecosystem, including the Ayushman Bharat Digital Mission, eSanjeevani, CoWIN, and AI-driven surveillance platforms, is enabling broader access, longitudinal data integration, and precision public health interventions. This synergistic integration of omics science with digital platforms exemplifies a shift from reactive to proactive, personalized, and equitable healthcare. The article highlights how these national efforts collectively advance the principles of 4P medicine: Predictive, Preventive, Personalized, and Participatory, and set a precedent for precision health implementation in diverse, resource-limited settings globally.